生物技术系-韩英浩

韩英浩个人简介

韩英浩，男，1972年，2005年博士毕业于韩国忠南大学，教授/硕导，中共党员。先后主持过省部级及厅局级项目5项，指导省/校级大创、研创10余项。发表SCI论文60余篇，授权国家发明专利1项，出版专著1部。主讲《发育生物学》、《细胞生物学》、《干细胞技术与应用》、《高级细胞生物学》等课程。科研方向为通过疾病模式动物结合细胞生物学、生物信息学等方法研究基因在人类疾病中的作用机制，包括干细胞治疗、神经退行性疾病、癌症及代谢病等领域的研究。

◆ 教研成果

（1）项目及获奖

面向生命科学的人体实验实践基地建设（202101099051），国家教育部，2021.1-2024.5，主持人

研究生核心课程建设项目（HXKC202113），黑龙江八一农垦大学，2021.11-2024.11，主持人

（2）指导学生“双创”情况

毛莹莹. 研究生创新科研项目，Prx II敲除通过激活Akt/GSK3β/β-catenin上调CXCR6促进DMSCs向关节炎损伤部位归巢，YJHSCX2021-Y102，黑龙江八一农垦大学，2021.05-2022.05，结题

孙率洋，杨翼，刘昊橙，许汶珈，王连浩。大学生创新创业项目（省级），酒精性肝病发展中mRNA-micRNA-lncRNA调控网络的构建，S202310223099，黑龙江省教育厅，2022.05-2023.05.

刘昊橙，许汶珈，宋伟民，杨翼。大学生创新创业项目（国家级），Prx II-RBP-microRNA调控网络在干细胞外泌体介导急性肺损伤修复中的作用研究，202410223072，黑龙江省教育厅，2023.05-2024.05.

许汶珈，胡韵琳，陈雪，陈思源，杨锦宏。大学生创新创业项目（省级），Prx II调控氧化应激抑制黄曲霉毒素B1诱导肝细胞脂滴蓄积的作用研究，黑龙江省教育厅，2025.05-2026.05.

◆ 科研成果：

（1）项目及获奖

基于ISG15类泛素化调控间充质干细胞分泌外泌体促进急性肺损（LH2021C061），黑龙江省科技厅，10.0万元，2021.7-2024.7，主持人

博来霉素诱导肺纤维化过程中Prx I的调控作用机制（LH2022C060），黑龙江省科技厅，2022.07 – 2024.07，10.0万元，在研, 第二参与人

PrxII调控内质网线粒体互作保护海马线粒体氧化损伤的机制（LH2023C076），黑龙江省科技厅，2023.07 – 2026.07，10.0万元，在研, 第二参与人

Prx I调控Fas受体膜转运介导肝癌细胞失巢凋亡的机制研究LH2021C061），黑龙江省科技厅，10.0万元，2024.12-2027.12，主持人

（2）论文及专著

Mei-Hua Jin, Lin Feng, Hong-Yi Xiang, Hu-Nan Sun, Ying-Hao Han and Taeho Kwon. Exploring the role of Prx II in mitigating endoplasmic reticulum stress and mitochondrial dysfunction in neurodegeneration. Cell Commun Signal. 2024 Apr 18;22(1):231.（通讯）

Mei-Hua Jin , Xiao-Dong Liu, Hu-Nan Sun, Ying-Hao Han, Taeho Kwon. Peroxiredoxin II exerts neuroprotective effects by inhibiting endoplasmic reticulum stress and oxidative stress-induced neuronal pyroptosis. Mol Biol Rep. 2024 May 5;51(1):607. （通讯）

Ying-Hao Han, Ying-Ying Mao, Kyung Ho Lee, Hee Jun Cho, Nan-Nan Yu, Xiao-Ya Xing, Ai-Guo Wang, Mei-Hua Jin, Kwan Soo Hong, Hu-Nan Sun and Taeho Kwon. Peroxiredoxin II regulates exosome secretion from dermal mesenchymal stem cells through the ISGylation signaling pathway. Cell Commun Signal. 2023 Oct 20;21(1):296.

Ying-Hao Han, Xiao-Dong Liu, Mei-Hua Jin, Hu-Nan Sun and Taeho Kwon. Role of NLRP3 inflammasome-mediated neuronal pyroptosis and neuroinflammation in neurodegenerative diseases. Inflamm Res. 2023 Sep;72(9):1839-1859.

Ying-Hao Han, Lin Feng, Seung-Jae Lee, Yong-Qing Zhang, Ai-Guo Wang, Mei-Hua Jin, Hu-Nan Sun and Taeho Kwon. Depletion of peroxiredoxin II promotes keratinocyte apoptosis and alleviates psoriatic skin lesions via the PI3K/AKT/GSK3β signaling axis. Cell Death Discov. 2023 Jul 27;9(1):263.

Ying-Hao Han, DA-Yu Ma, Seung-Jae Lee, Ying-Ying Mao, Shuai-Yang Sun, Mei-Hua Jin, Hu-Nan Sun and Taeho Kwon. Bioinformatics Analysis of Novel Targets for Treating Cervical Cancer by Immunotherapy Based on Immune Escape. Cancer Genomics Proteomics. 2023 Jul-Aug; 20(4): 383-397.

Ying-Hao Han, Xiao-Ya Xing, Dong Hun Lee, Ying-Ying Mao, Mei-Hua Jin, Hu-Nan Sun and

Taeho Kwon. Induction of Targeted Differentiation of Dermal Mesenchymal Stem Cells Into Neural Lineage According to Peroxiredoxin II Expression. In Vivo. 2023 Jul-Aug;37(4):1593-1602.

Ying-Hao Han, Yuan Wang, Seung-Jae Lee, Ying-Ying Mao, Peng Jiang, Hu-Nan Sun, Mei-Hua Jin, Taeho Kwon. Identification of Hub Genes and Upstream Regulatory Factors Based on Cell Adhesion in Triple-negative Breast Cancer by Integrated Bioinformatical Analysis. Anticancer Res. 2023 Jul;43(7):2951-2964.

Ying-Hao Han, Xin-Mei He, Mei-Hua Jin, Hu-Nan Sun and Taeho Kwon. Lipophagy: A potential therapeutic target for nonalcoholic and alcoholic fatty liver disease. Biochem Biophys Res Commun . 2023 Sep 10:672:36-44.

Taeho Kwon, Hong-Yi Xiang, Xiao-Ya Xing, Peng Jiang, Shuai-Yang Sun, Hu-Nan Sun, Ying-Hao Han. Regulatory pathway underpinning the development of encephalitis after simian immunodeficiency virus infection in rhesus macaques (Macaca mulatta). J Med Primatol. 2023 Aug;52(4):259-271. （通讯）

Ying-Hao Han, Ying-Ying Mao, Yao-Yuan Feng, Hong-Yi Xiang, Hu-Nan Sun, Mei-Hua Jin Taeho Kwon. Identification of peroxiredoxin II and its related molecules as potential biomarkers of dermal mesenchymal stem cell homing using network analysis. Applied Biological Chemistry. 2022 June 65.37:1-12

Ying-Hao Han, Xu-Dong Lian, Seung-Jae Lee, Wei-Long Li, Hu-Nan Sun, Mei-Hua Jin & Taeho Kwon. Regulatory effect of peroxiredoxin 1 (PRDX1) on doxorubicin-induced apoptosis in triple negative breast cancer cells. Applied Biological Chemistry. 2022 Sep. 65.63:1-17

Wengeng Lu, Zheng-Mei Xu, Qing Liu, Nan-Nan Yu, Jia-Bin Yu, Wei-Long Li, Ying-Ying Mao, Zhenzhen Du, Linqing Si, Siqi Yuan, Jidong Jin, Shixin Fu, Dongbo Sun and Ying-Hao Han. Inhibitory Effect of Bovine Adipose-Derived Mesenchymal Stem Cells on Lipopolysaccharide Induced Inflammation of Endometrial Epithelial Cells in Dairy Cows. Front Vet Sci. 2021 Oct 21:8:726328.（共同通讯）

Gui-Nan Shen, Jing Li, Ying-Hua Jin, Hu-Nan Sun, Ying-Ying Hao, Mei-Hua Jin, Ren Liu, Wei-Long Li, Yong-Qing Zhang, Jia-Bin Yu, Nan-Nan Yu, Wei-Dong Wang, Li-Yun Yu, Ji-Su Kim, Taeho Kwon, and Ying-Hao Han. The compound 2-benzylthio-5,8-dimethoxynaphthalene-1,4-dione leads to apoptotic cell death by increasing the cellular reactive oxygen species levels in Ras-mutated liver cancer cells. Exp Ther Med. 2020 Nov;20(5):82.（通讯）

Ying-Hao Han, Yong-Qing Zhang, Mei-Hua Jin, Ying-Hua Jin, Mei-Yu Qiu, Wei-Long Li, Chao He, Li-Yun Yu, Jin Won Hyun, Jiyon Lee, Do-Young Yoon, Hu-Nan Sun, Taeho Kwon. Peroxiredoxin I deficiency increases keratinocyte apoptosis in a skin tumor model via the ROS-p38 MAPK pathway. Biochem Biophys Res Commun. 2020 Aug 27;529(3):635-641.

Ying-Hao Han, Wei-Long Li, Mei-Hua Jin, Ying-Hua Jin, Young-Qing Zhang, Ling-Zu Kong, Li-Yun Yu, Jin Won Hyun, Jeongwoo Kwon, Hu-Nan Sun, Taeho Kwon. Peroxiredoxin II Inhibits Alcohol-induced Apoptosis in L02 Hepatocytes Through AKT/β-Catenin Signaling Pathway. Anticancer Res. 2020 Aug;40(8):4491-4504.

Mei-Hua Jin, Gui-Nan Shen, Ying-Hua Jin, Hu-Nan Sun, Xing Zhen, Yong-Qing Zhang, Dong-Seok Lee, Yu-Dong Cui, Li-Yun Yu, Ji-Su Kim, Taeho Kwon and Ying-Hao Han. Peroxiredoxin I deficiency increases pancreatic β cell apoptosis after streptozotocin stimulation via the AKT/GSK3β signaling pathway. Mol Med Rep. 2020 Sep;22(3):1831-1838.（通讯）

Ying-Hao Han, Mei-Hua Jin, Ying-Hua Jin, Nan-Nan Yu, Jun Liu, Yong-Qing Zhang, Yu-Dong Cui, Ai-Guo Wang, Dong-Seok Lee, Sun-Uk Kim, Ji-Su Kim, Taeho Kwon, Hu-Nan Sun. Deletion of Peroxiredoxin II Inhibits the Growth of Mouse Primary Mesenchymal Stem Cells Through Induction of the G0/G1 Cell-cycle Arrest and Activation of AKT/GSK3β/β-Catenin Signaling. In Vivo. 2020 Jan-Feb;34(1):133-141.

Mei-Hua Jin, Jia-Bin Yu, Hu-Nan Sun, Ying-Hua Jin, Gui-Nan Shen, Cheng-Hao Jin, Yu-Dong Cui, Dong-Seok Lee, Sun-Uk Kim, Ji-Su Kim, Taeho Kwon, Ying-Hao Han. Peroxiredoxin II Maintains the Mitochondrial Membrane Potential against Alcohol-Induced Apoptosis in HT22 Cells. Antioxidants (Basel). 2019 Dec 18;9(1):1.（通讯）

（3）发明专利