生物技术系-韩英浩

发布者：白巍发布时间：2019-11-14浏览次数：2440

韩英浩，男，1972年，2005年博士毕业于韩国忠南大学，副教授/硕导，中共党员。先后主持过省部级及厅局级项目4项，指导省/校级大创、研创10余项。发表SCI论文60余篇，授权国家发明专利1项，出版专著1部。主讲《发育生物学》、《细胞生物学》、《干细胞技术与应用》、《高级细胞生物学》等课程。科研方向为通过疾病模式动物结合细胞生物学、生物信息学等方法研究基因在人类疾病中的作用机制，包括干细胞治疗、神经退行性疾病、癌症及代谢病等领域的研究。

◆ 教研成果

（1）项目及获奖

面向生命科学的人体实验实践基地建设（202101099051），国家教育部，2021.1-2024.5，主持人

（2）指导学生“双创”情况

毛莹莹. 研究生创新科研项目，Prx II敲除通过激活Akt/GSK3β/β-catenin上调CXCR6促进DMSCs向关节炎损伤部位归巢，YJHSCX2021-Y102，黑龙江八一农垦大学，2021.05-2022.05，结题

孙率洋，杨翼，刘昊橙，许汶珈，王连浩。大学生创新创业项目，酒精性肝病发展中mRNA-micRNA-lncRNA调控网络的构建，S202310223099，黑龙江省教育厅，2022.05-2023.05.

◆ 科研成果：

（1）项目及获奖

基于ISG15类泛素化调控间充质干细胞分泌外泌体促进急性肺损（LH2021C061），黑龙江省科技厅，10.0万元，2021.7-2024.7，主持人

PrxII调控内质网线粒体互作保护海马线粒体氧化损伤的机制，（LH2023C076），黑龙江省科技厅，2023.07 – 2026.07，10.0万元，在研, 第二参与人

博来霉素诱导肺纤维化过程中Prx I的调控作用机制（LH2022C060），黑龙江省科技厅，2023.07 – 2026.07，10.0万元，在研, 第二参与人

（2）论文及专著

Mei-Hua Jin, Lin Feng, Hong-Yi Xiang, Hu-Nan Sun, Ying-Hao Han and Taeho Kwon. Exploring the role of Prx II in mitigating endoplasmic reticulum stress and mitochondrial dysfunction in neurodegeneration. Cell Commun Signal. 2024 Apr 18;22(1):231.

Shuai-Yang Sun, Dong Hun Lee2, Hao-Cheng Liu, Yi Yang, Ying-Hao Han and Taeho Kwon. Identifying competing endogenous RNA regulatory networks and hub genes in alcoholic liver disease for early diagnosis and potential therapeutic target insights. Aging (Albany NY). 2024 May 1;15(16):1-21.

Ying-Hao Han, Hong-Yi Xiang, Dong Hun Lee, Lin Feng, Hu-Nan Sun, Mei-Hua Jin, Taeho Kwon. Identification and diagnostic potential of serum microRNAs as biomarkers for early detection of Alzheimer's disease. Aging (Albany NY). 2023 Nov 1;15(21):12085-12103.

Ying-Hao Han, Ying-Ying Mao, Kyung Ho Lee, Hee Jun Cho, Nan-Nan Yu, Xiao-Ya Xing, Ai-Guo Wang, Mei-Hua Jin, Kwan Soo Hong, Hu-Nan Sun and Taeho Kwon. Peroxiredoxin II regulates exosome secretion from dermal mesenchymal stem cells through the ISGylation signaling pathway. Cell Commun Signal. 2023 Oct 20;21(1):296.

Ying-Hao Han, Xiao-Dong Liu, Mei-Hua Jin, Hu-Nan Sun and Taeho Kwon. Role of NLRP3 inflammasome-mediated neuronal pyroptosis and neuroinflammation in neurodegenerative diseases. Inflamm Res. 2023 Sep;72(9):1839-1859.

Ying-Hao Han, Lin Feng, Seung-Jae Lee, Yong-Qing Zhang, Ai-Guo Wang, Mei-Hua Jin, Hu-Nan Sun and Taeho Kwon. Depletion of peroxiredoxin II promotes keratinocyte apoptosis and alleviates psoriatic skin lesions via the PI3K/AKT/GSK3β signaling axis. Cell Death Discov. 2023 Jul 27;9(1):263.

Ying-Hao Han, DA-Yu Ma, Seung-Jae Lee, Ying-Ying Mao, Shuai-Yang Sun, Mei-Hua Jin, Hu-Nan Sun and Taeho Kwon. Bioinformatics Analysis of Novel Targets for Treating Cervical Cancer by Immunotherapy Based on Immune Escape. Cancer Genomics Proteomics. 2023 Jul-Aug; 20(4): 383-397.

Ying-Hao Han, Xiao-Ya Xing, Dong Hun Lee, Ying-Ying Mao, Mei-Hua Jin, Hu-Nan Sun and

Taeho Kwon. Induction of Targeted Differentiation of Dermal Mesenchymal Stem Cells Into Neural Lineage According to Peroxiredoxin II Expression. In Vivo. 2023 Jul-Aug;37(4):1593-1602.

Ying-Hao Han, Yuan Wang, Seung-Jae Lee, Ying-Ying Mao, Peng Jiang, Hu-Nan Sun, Mei-Hua Jin, Taeho Kwon. Identification of Hub Genes and Upstream Regulatory Factors Based on Cell Adhesion in Triple-negative Breast Cancer by Integrated Bioinformatical Analysis. Anticancer Res. 2023 Jul;43(7):2951-2964.

Ying-Hao Han, Xin-Mei He, Mei-Hua Jin, Hu-Nan Sun and Taeho Kwon. Lipophagy: A potential therapeutic target for nonalcoholic and alcoholic fatty liver disease. Biochem Biophys Res Commun . 2023 Sep 10:672:36-44.

Taeho Kwon, Hong-Yi Xiang, Xiao-Ya Xing, Peng Jiang, Shuai-Yang Sun, Hu-Nan Sun, Ying-Hao Han. Regulatory pathway underpinning the development of encephalitis after simian immunodeficiency virus infection in rhesus macaques (Macaca mulatta). J Med Primatol. 2023 Aug;52(4):259-271.

Ying-Hao Han, Ying-Ying Mao, Yao-Yuan Feng, Hong-Yi Xiang, Hu-Nan Sun, Mei-Hua Jin Taeho Kwon. Identification of peroxiredoxin II and its related molecules as potential biomarkers of dermal mesenchymal stem cell homing using network analysis. Applied Biological Chemistry. 2022 June 65.37:1-12

Ying-Hao Han, Xu-Dong Lian, Seung-Jae Lee, Wei-Long Li, Hu-Nan Sun, Mei-Hua Jin & Taeho Kwon. Regulatory effect of peroxiredoxin 1 (PRDX1) on doxorubicin-induced apoptosis in triple negative breast cancer cells. Applied Biological Chemistry. 2022 Sep. 65.63:1-17

Ying-Hao Han, Xin-Mei He, Seung-Jae Lee, Ying-Ying Mao, Xuan-Chen Liu, Hu-Nan Sun, Mei-Hua Jin, Taeho Kwon. Network analysis for the identification of hub genes and related molecules as potential biomarkers associated with the differentiation of bone marrow-derived stem cells into hepatocytes. Aging (Albany NY). 2022 Oct 20;14(20):8243-8257.

Wengeng Lu, Zheng-Mei Xu, Qing Liu, Nan-Nan Yu, Jia-Bin Yu, Wei-Long Li, Ying-Ying Mao, Zhenzhen Du, Linqing Si, Siqi Yuan, Jidong Jin, Shixin Fu, Dongbo Sun and Ying-Hao Han. Inhibitory Effect of Bovine Adipose-Derived Mesenchymal Stem Cells on Lipopolysaccharide Induced Inflammation of Endometrial Epithelial Cells in Dairy Cows. Front Vet Sci. 2021 Oct 21:8:726328.

Mei-Hua Jin, Nan-Nan Yu, Ying-Hua Jin, Ying-Ying Mao, Lin Feng, Yue Liu, Ai-Guo Wang, Hu-Nan Sun, Taeho Kwon, Ying-Hao Han. Peroxiredoxin II with dermal mesenchymal stem cells accelerates wound healing. Aging (Albany NY). 2021 May 24;13(10):13926-13940.

Gui-Nan Shen, Jing Li, Ying-Hua Jin, Hu-Nan Sun, Ying-Ying Hao, Mei-Hua Jin, Ren Liu, Wei-Long Li, Yong-Qing Zhang, Jia-Bin Yu, Nan-Nan Yu, Wei-Dong Wang, Li-Yun Yu, Ji-Su Kim, Taeho Kwon, and Ying-Hao Han. The compound 2-benzylthio-5,8-dimethoxynaphthalene-1,4-dione leads to apoptotic cell death by increasing the cellular reactive oxygen species levels in Ras-mutated liver cancer cells. Exp Ther Med. 2020 Nov;20(5):82.

Ying-Hao Han, Yong-Qing Zhang, Mei-Hua Jin, Ying-Hua Jin, Mei-Yu Qiu, Wei-Long Li, Chao He, Li-Yun Yu, Jin Won Hyun, Jiyon Lee, Do-Young Yoon, Hu-Nan Sun, Taeho Kwon. Peroxiredoxin I deficiency increases keratinocyte apoptosis in a skin tumor model via the ROS-p38 MAPK pathway. Biochem Biophys Res Commun. 2020 Aug 27;529(3):635-641.

Ying-Hao Han, Wei-Long Li, Mei-Hua Jin, Ying-Hua Jin, Young-Qing Zhang, Ling-Zu Kong, Li-Yun Yu, Jin Won Hyun, Jeongwoo Kwon, Hu-Nan Sun, Taeho Kwon. Peroxiredoxin II Inhibits Alcohol-induced Apoptosis in L02 Hepatocytes Through AKT/β-Catenin Signaling Pathway. Anticancer Res. 2020 Aug;40(8):4491-4504.

Mei-Hua Jin, Gui-Nan Shen, Ying-Hua Jin, Hu-Nan Sun, Xing Zhen, Yong-Qing Zhang, Dong-Seok Lee, Yu-Dong Cui, Li-Yun Yu, Ji-Su Kim, Taeho Kwon and Ying-Hao Han. Peroxiredoxin I deficiency increases pancreatic β‑cell apoptosis after streptozotocin stimulation via the AKT/GSK3β signaling pathway. Mol Med Rep. 2020 Sep;22(3):1831-1838.

Ying-Hao Han, Mei-Hua Jin, Ying-Hua Jin, Nan-Nan Yu, Jun Liu, Yong-Qing Zhang, Yu-Dong Cui, Ai-Guo Wang, Dong-Seok Lee, Sun-Uk Kim, Ji-Su Kim, Taeho Kwon, Hu-Nan Sun. Deletion of Peroxiredoxin II Inhibits the Growth of Mouse Primary Mesenchymal Stem Cells Through Induction of the G0/G1 Cell-cycle Arrest and Activation of AKT/GSK3β/β-Catenin Signaling. In Vivo. 2020 Jan-Feb;34(1):133-141.

Mei-Hua Jin, Jia-Bin Yu, Hu-Nan Sun, Ying-Hua Jin, Gui-Nan Shen, Cheng-Hao Jin, Yu-Dong Cui, Dong-Seok Lee, Sun-Uk Kim, Ji-Su Kim, Taeho Kwon, Ying-Hao Han. Peroxiredoxin II Maintains the Mitochondrial Membrane Potential against Alcohol-Induced Apoptosis in HT22 Cells. Antioxidants (Basel). 2019 Dec 18;9(1):1.

（3）发明专利