生物工程系-孙虎男

发布者:韦人月发布时间:2019-11-15浏览次数:610


孙虎男 副教授 简介   

 

E-Mail: sunhunan76@163.com                    

Mobile: 18745968262             

孙虎男(1978.01-),男,博士,副教授。2008年在韩国忠南大学校兽医大学获得兽医机能学博士学位,之后在韩国生命工学研究院细胞治疗研究室从事博士后研究。硕士、博士学位期间均在韩国生命工学研究院研究,先后在疾病模式动物研究中心,老化研究中心及细胞治疗研究室从事活性氧与疾病治疗,抗氧化物酶功能研究和抗癌药物筛选研究等。 2010年回家就职于黑龙江八一农垦大学生命科学技术学院,组建了干细胞治疗与再生生物学实验室2019年应邀在济州大学做了半年的研究教授,引进低温等离子体技术。目前主要从事抗癌药物筛选和过氧化物酶功能研究和低温等离子体生物学效应研究。主持省部级项目2项,厅局级项目2项,校级项目3项,参加2项国家自然基金,指导多项大创、研创项目。近三年,发表SCI论文35篇,其中第一(共同第一)15篇,通讯(共同通讯)11篇,撰写专著1篇。 获得厅局级科技进步二等奖1项,大庆市第二十六届自然科学学术成果二等奖1项。 目前,主讲本科细胞生物学课程和研究生细胞信号传导动物组织细胞培养技术等课程。担任Theranotics, International journal of molecular medicine,journal of cancer reasearch and clinical oncology  10余个期刊审稿人。

 

发表论文

Sun HN, Kim SU, Huang SM, Kim JM, Park YH, Kim SH, Yang HY, Chung KJ, Lee TH, Choi HS, Min JS, Park MK, Kim SK, Lee SR, Chang KT, Lee SH, Yu DY, Lee DS. Microglial peroxiredoxin V acts as an inducible anti-inflammatory antioxidant through cooperation with redox signaling cascades. J Neurochem. 2010 Jul;114(1):39-50. (中科院SCI期刊分区 2IF=4.6代表作)

GuiNan Shen, Lei Liu, Li Feng, Yu Jin, MeiHua Jin, YingHao Han, ChengHao Jin, YongZhe Jin, DongSoek Lee, Tae Ho Kwon, YuDong Cui &  HuNan Sun*. Knockdown of Peroxiredoxin V incrases glutamate-induced apoptosis in HT22 hippocampal neuron cells. Mol Med Rep. 2018 Jun;17(6):7827-7834.  (中科院SCI期刊分区 4IF=1.922代表作)

Liu Y, Kwon T, Kim JS, Chandimali N, Jin YH, Gong YX, Xie DP, Han YH, Jin MH, Shen GN, Jeong DK, Lee DS, Cui YD and Sun HN*. Peroxiredoxin V Reduces β-Lapachone-induced Apoptosis of Colon Cancer Cells. Anticancer Res. 2019 Jul;39(7):3677-3686. (中科院SCI期刊分区 4IF=1.8代表作)

Han YH, Zhang YQ, Jin MH, Jin YH, Qiu MY, Li WL, He C, Yu LY, Hyun JW, Lee J, Yoon DY, Sun HN (co-correspondence), Kwon T. Peroxiredoxin I deficiency increases keratinocyte apoptosis in a skin tumor model via the ROS-p38 MAPK pathway. Biochem Biophys Res Commun. 2020 Aug 27;529(3):635-641. (中科院SCI期刊分区 3IF=3.0代表作)

Hu-Nan Sun, Li Feng, Ai-Guo Wang, Jing-Yu Wang, Lei Liu, Mei-Hua Jin, Gui-Nan Shen, Cheng-Hao Jin, Dong-Soek Lee, Tea-Ho Kwon, Yu-Dong Cui, Dae-Yeul Yu & Ying-Hao Han. Peroxiredoxin I deficiency increases LPS-induced lethal shock in mice. Mol Med Rep. 2018   (中科院SCI期刊分区 4IF=1.922代表作)

Sun HN, Liu Y, Wang JN, Wang C, Liu R, Kong LZ, Zhen X, Chandimali N, Cui YD, Kim SU, Lee DS, Yu DY, Kim JS, Jeong DK, Kwon T, Han YH. Protective Role of Peroxiredoxin I in Heat-Killed Staphylococcus Aureus-infected Mice. In Vivo. 2019 May-Jun;33(3):749-755 (中科院SCI期刊分区 4IF=1.6代表作)

HU-NAN SUN, CHEN-XI REN, YI-XI GONG1, DAN-PING XIE and TAEHO KWON. Regulatory function of peroxiredoxin I on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induced lung cancer development. Oncology Letter  (Accepted) 2021, Review  (中科院SCI期刊分区 4IF=2.3

Chandimali N, Sun HN(co-first), Kong LZ, Zhen X, Liu R, Kwon T, Lee DS. Shikonin-induced Apoptosis of Colon Cancer Cells Is Reduced by Peroxiredoxin V Expression. Anticancer Res. 2019 Nov;39(11):6115-6123. (中科院SCI期刊分区 4IF=1.9)

Sun HN, Luo YH, Meng LQ, Piao XJ, Wang Y, Wang JR, Wang H, Zhang Y, Li JQ, Xu WT, Liu Y, Zhang Y, Zhang T, Han YH, Jin MH, Shen GN, Zang YQ, Cao LK, Zhang DJ, Jin CH.  Cryptotanshinone induces reactive oxygen speciesmediated apoptosis in human rheumatoid arthritis fibroblastlike synoviocytes. Int J Mol Med. 2019 Feb;43(2):1067-1075. (中科院SCI期刊分区 3IF=2.778

 Xie DP, Gong YX, Jin YH, Ren CX, Liu Y, Han YH, Jin MH, Zhu D, Pan QZ, Yu LY, Lee DS, Lee J, Kim J, Park YH, Hyun JW, Kwon T, Cui YD, Sun HN*.Anti-tumor Properties of Picrasma quassioides Extracts in H-Ras G12V Liver Cancer Are Mediated Through ROS-dependent Mitochondrial Dysfunction. Anticancer Res. 2020 Jul;40(7):3819-3830  (中科院SCI期刊分区 4IF=1.8)

 Gong YX, Liu Y, Jin YH, Jin MH, Han YH, Li J, Shen GN, Xie DP, Ren CX, Yu LY, Lee DS, Kim JS, Jo YJ, Kwon J, Lee J, Park YH, Kwon T, Cui YD, Sun HN* Picrasma quassioides Extract Elevates the Cervical Cancer Cell Apoptosis Through ROS-Mitochondrial Axis Activated p38 MAPK Signaling Pathway. In Vivo. 2020 Jul-Aug;34(4):1823-1833 (中科院SCI期刊分区 4IF=1.6)

 Sun HN, Jin MH, Han B, Feng L, Han YH, Shen GN, Yu YZ, Jin CH, Lian ZX, Lee DS, Kim SU, Ge WZ, Cui YD. 16α,17α-Epoxypregnenolone-20-oxime prevent LPS-induced NO production and iNOS expression in BV-2 microglial cells by inhibiting JNK phosphorylation. Biol Pharm Bull. 2014;37(7):1096-102. (中科院SCI期刊分区 4区,IF=1.694)

 Sun HN, Han YH, Feng L, Jin CH, Han B, Liu L, Lee DS, Kwon TH, Li LG, Ge WZ, Cui YD. 16α, 17α-epoxypregnenolone-20-oxime inhibits NO and IL-6 production in LPS-treated RAW264.7 cells. Mol Med Rep. 2016 Jun;13(6):4927-33  (中科院SCI期刊分区 4IF=1.922)

 Sun HN, Luo YH, Meng LQ, Piao XJ, Wang Y, Wang JR, Wang H, Zhang Y, Li JQ, Xu WT, Liu Y, Zhang Y, Zhang T, Han YH, Jin MH, Shen GN, Zang YQ, Cao LK, Zhang DJ, Jin CH.  Cryptotanshinone induces reactive oxygen speciesmediated apoptosis in human rheumatoid arthritis fibroblastlike synoviocytes. Int J Mol Med. 2019 Feb;43(2):1067-1075. (中科院SCI期刊分区 3IF=2.78)

 Kong LZ, Chandimali N, Han YH, Lee DH, Kim JS, Kim SU, Kim TD, Jeong DK, Sun HN(co-correspondence), Lee DS, Kwon T. Pathogenesis, Early Diagnosis, and Therapeutic Management of Alcoholic Liver Disease. Int J Mol Sci. 2019 Jun 2;20(11). (中科院SCI期刊分区 3区,IF=4.18)Review.

 Chandimali N, Sun HN(co-first), Park YH, Kwon T. BRM270 Suppresses Cervical Cancer Stem Cell Characteristics and Progression by Inhibiting SOX2. In Vivo. 2020 May-Jun;34(3):1085-1094. (中科院SCI期刊分区 4, IF=1.6

 Koh H, Sun HN (co-first), Xing Z, Liu R, Chandimali N, Kwon T, Lee DS. Wogonin Influences Osteosarcoma Stem Cell Stemness Through ROS-dependent Signaling. In Vivo. 2020 May-Jun;34(3):1077-1084. (中科院SCI期刊分区 4, IF=1.6

 Zhen X, Sun HN(co-first), Liu R, Choi HS, Lee DS. Non-thermal plasma-activated Medium Induces Apoptosis of Aspc1 Cells Through the ROS-dependent Autophagy Pathway. In Vivo. 2020 Jan-Feb;34(1):143-153. (中科院SCI期刊分区 4, IF=1.6

 Chandimali N, Sun HN(co-first), Kong LZ, Zhen X, Liu R, Kwon T, Lee DS. Shikonin-induced Apoptosis of Colon Cancer Cells Is Reduced by Peroxiredoxin V Expression. Anticancer Res. 2019 Nov;39(11):6115-6123. (中科院SCI期刊分区 4,  IF=1.8)

 Jin YZ, Sun HN(co-first), Liu Y, Lee DH, Kim JS, Kim SU, Jiao BY, Han YH, Jin MH, Shen GN, Lee DS, Kwon T, Xu DY, Jin YU. Peroxiredoxin V Inhibits Emodin-induced Gastric Cancer Cell Apoptosis via the ROS/Bcl2 Pathway. In Vivo. 2019 Jul-Aug;33(4):1183-1192. 中科院SCI期刊分区 4, IF=1.6

 Liu C, Sun HNco-first, Luo YH, Piao XJ, Wu DD, Meng LQ, Wang Y, Zhang Y, Wang JR, Wang H, Xu WT, Li JQ, Liu Y, Wu YQ, Han YH, Shen GN, Jin MH, Zang YQ, Li JC, Fang NZ, Cui YD, Jin CH. Cryptotanshinone induces ROS-mediated apoptosis in human gastric cancer cells. Oncotarget. 2017 Dec 15;8(70): (IF=5.0)

 Liang WF, Gong YX, Li HF, Sun FL, Li WL, Chen DQ, Xie DP, Ren CX, Guo XY, Wang ZY, Kwon T, Sun HN.  Curcumin Activates ROS Signaling to Promote Pyroptosis in Hepatocellular Carcinoma HepG2 Cells. In Vivo. 2021 Jan-Feb;35(1):249-257.(中科院SCI期刊分区 4, IF=1.6

 Han YH, Li WL, Jin MH, Jin YH, Zhang YQ, Kong LZ, Yu LY, Hyun JW, Kwon J, Sun HN (co-correspondence), Kwon T. Peroxiredoxin II Inhibits Alcohol-induced Apoptosis in L02 Hepatocytes Through AKT/β-Catenin Signaling Pathway. Anticancer Res. 2020 Aug;40(8):4491-4504. .(中科院SCI期刊分区 4, IF=1.9

 Han YH, Jin MH, Jin YH, Yu NN, Liu J, Zhang YQ, Cui YD, Wang AG, Lee DS, Kim SU, Kim JS, Kwon T, Sun HN*. Deletion of Peroxiredoxin II Inhibits the Growth of Mouse Primary Mesenchymal Stem Cells Through Induction of the G0/G1 Cell-cycle Arrest and Activation of AKT/GSK3β/β-Catenin Signaling. In Vivo. 2020 Jan-Feb;34(1):133-141. (中科院SCI期刊分区 4,  IF=1.6)

 YingHao Han†, DongQin Chen†, MeiHua Jin†, YingHua Jin , Jing Li, GuiNan Shen , WeiLong Li, YiXi Gong, YingYing Mao, DanPing Xie, DongSeok Lee, LiYun Yu, SunUk Kim, JiSu Kim ,Taeho Kwon* , YuDong Cui*and HuNan Sun* Anti-infammatory efect of hispidin on LPS induced macrophage infammation through MAPK and JAK1/STAT3 signaling pathways. Appl Biol Chem (2020) 63:21 (中科院SCI期刊分区 4,  IF=1.6)

 Han B (#)Shin HjBak ISJeong YLKwon TSun HNKin CHYu DY(*)  Peroxiredoxin I is important for cancer-cell survival in Ras-induced hepatic tumorigenesis.Oncotarget.2016.01.01187):68044~68056

 Kim, Tae-Don(#)Lee, Su UiYun, SohyunSun Hu-NanLee, Suk HyungKim, Jae WhaKim, Hwan MookPark, Song-KyuLee, Chang WooYoon, Suk RanGreenberg, Philip DChoi, InpyoHuman microRNA-27a* targets Prf1 and GzmB expression to regulate NK-cell cytotoxicity.Blood2011.11.1711820):5476~5486 (中科院SCI期刊分区 1,  IF=17.54)

 Mei-Hua Jin , Jia-Bin Yu , Hu-Nan SunYing-Hua JinGui-Nan ShenCheng-Hao JinYu-Dong Cui , Dong-Seok LeeSun-Uk KimJi-Su KimTaeho KwonYing-Hao Han  Peroxiredoxin II Maintains the Mitochondrial Membrane Potential against Alcohol-Induced Apoptosis in HT22 Cells. Antioxidants (Basel). 2019 Dec 18;9(1):1. doi: 10.3390/antiox9010001 (中科院SCI期刊分区 2,  IF=5.0)